阿斯利康
Senior Scientist II, Cell Therapy Discovery-Allogeneic CAR-T
Senior Scientist II, Cell Therapy Discovery-Allogeneic CAR-T
发布于 6 个月前普通员工/个人贡献者
上海市
高级经验
全职员工
仅现场办公
博士
研究与开发 (研发)
免疫学
基因编辑
慢病毒载体
细胞疗法
英语沟通
项目管理
CAR-T
早期研发
AI 估算 · 45k–75k
该职位要求博士学历和细胞疗法领域高级研发经验，涉及基因编辑、CAR-T等前沿技术，专业壁垒高，市场人才稀缺，薪资竞争力强。
职位详情
关于这个职位
这是一个专注于细胞疗法早期研发的高级科学家职位
你将参与同种异体CAR-T等细胞治疗产品的早期项目研究和技术策略设计，负责实验验证、数据分析和跨部门协作，推动创新疗法从概念走向现实
最低要求
Essential:
PhD or equivalent experience in a relevant subject
Has early-stage research and development experience in the field of cell therapy
Excellent knowledge of scientific literature, with a deep understanding of allogeneic CAR-T, viral vectors, and gene editing technologies.
Expertise in gene editing technologies.
Fluent in English, with the ability to report and present daily work in English.
Strong communication skills and experience in cross-functional collaboration.
Ability to identify risks and escalate appropriately.
Skills & Capabilities:
Proficiency in gene editing technologies or technical expertise in the CAR-T field.
Ability to work independently in designing, executing, and interpreting tasks.
Good interpersonal skills and ability to work collaboratively within teams and across departments.
Capability of fluent English communication and writing.
Strong sense of responsibility in work.
A confident team player who is assertive, yet open to listening and learning from the perspectives of others.
Ability to influence within own discipline and apply constructive challenges.
Excellent organizational skills, with a proven ability to deliver high-quality work under pressure and within tight deadlines.
工作职责
Specifically, the role holder will:
Participate in early-stage research and technical strategy design for R&D projects.
Be accountable for carrying out experimental work related to the projects, collaborating with the team to successfully deliver early-stage R&D projects.
Be accountable for cross-departmental collaboration during the R&D process, ensuring efficient cooperation and timely project delivery.
The role holder is accountable for ensuring that all activities are carried out in alignment with AstraZeneca’s Code of Conduct, supporting policies, standards, and procedures, including the compliant management of budget, safety, health, and environmental considerations.
ROLE & RESPONSIBILITIES
Lead literature research related to the project.
Lead project activities, including but not limited to the exploration of new technologies, design of innovative experimental protocols, daily experimental work, and ensuring the accuracy and timeliness of data delivery.
Manage project data compilation, report writing, and relevant presentations.
Collaborate with internal colleagues and global partners across departments to coordinate projects, explore new solutions, and advance collaborative initiatives.
Build and maintain expertise in current and emerging technologies within the relevant field.
Demonstrate awareness of project cost and budget control.
Provide timely updates on project progress, report issues and challenges encountered, offer insights into new problems, and propose effective solutions.
Undertake small supervisory roles, and participate in skills transfer and training.
Monitor and ensure compliance with all AstraZeneca policies and standards as well as local laws and regulations, and promptly address any instances of non-compliance.
优先资格
Desirable:
Has an immunology background.
Early-stage research and development experience in the field of cell therapy, especially with universal cell therapy products,
Early-stage research and development experience in the field of cell therapy, especially with relevant R&D experience with lentiviral vectors; highly proficient in lentiviral vector modification, packaging, purification, and delivery.
Candidates with relevant project experience in gene editing are preferred.
Knowledge of industry compliance requirements, such as HGR, CBDT, data privacy, etc.
AI 洞察
优缺点分析
优点
- 平台优势：在全球顶尖药企阿斯利康工作，能接触最前沿的细胞治疗技术和全球研发资源，平台起点高
- 领域前景：细胞与基因治疗是生物医药最具潜力的方向之一，从事该领域研发技术积累价值高，职业前景广阔
- 技能复合：不仅锻炼前沿生物技术，还能提升项目管理、跨文化协作等综合能力，个人竞争力强
- 技术难度高：涉及基因编辑、CAR-T等复杂技术，实验周期长、不确定性大，对专业深度和问题解决能力要求极高
- 竞争激烈：该领域汇聚全球顶尖人才，需要持续学习以保持技术领先，内部晋升和外部市场竞争都较为激烈
- 适合拥有细胞/免疫学相关博士学位、具备扎实研发经验和强烈求知欲，希望在顶尖平台攻克前沿技术难题，并具备优秀协作和沟通能力的科研人才
缺点 / 挑战
- 工作压力大：作为早期研发核心，需在紧迫时间内交付高质量数据，并协调多方资源，工作强度和压力并存
角色解读
- 技术专家路径：深耕细胞与基因治疗领域，成为特定技术（如基因编辑、载体工程）的顶尖专家或首席科学家
- 项目管理路径：从领导具体实验项目，发展为管理更复杂的研发管线或技术平台的项目负责人
- 管理路径：凭借技术专长和协作经验，未来可向研发团队负责人、部门总监等管理岗位发展
- 负责细胞疗法（特别是同种异体CAR-T）的早期项目研究，包括文献调研、技术策略设计和实验方案创新
- 独立或带领团队执行实验，确保数据准确性和项目按时交付，并负责数据整理、报告撰写和成果汇报
- 与内部跨部门团队及全球合作伙伴紧密协作，协调项目进展，探索新解决方案，推动合作项目向前发展
- 核心是深厚的细胞疗法和基因编辑技术专长，特别是对同种异体CAR-T、病毒载体有深刻理解，并能熟练应用
- 需要具备独立设计和执行复杂实验的能力，以及优秀的数据分析和科学问题解决能力
- 必须具备流利的英语沟通和书面表达能力，用于日常汇报、跨团队协作和全球交流
- 需要强大的项目管理、跨部门协作和风险识别能力，能在压力下高质量交付工作
申请策略
- 深入了解阿斯利康在细胞治疗领域的研发管线、战略布局和最新动态，在申请和面试中展现你的行业洞察和兴趣
- 准备具体事例来证明你“独立设计执行任务”、“在压力下交付高质量工作”和“进行建设性挑战”的能力，这些是JD强调的软技能
- 重点突出在细胞疗法、基因编辑或相关领域的博士研究及博士后/工作经历，特别是早期研发项目的完整参与和贡献
- 详细描述与职位直接相关的技术技能，如具体的基因编辑工具（如CRISPR）、慢病毒载体操作经验、CAR-T相关实验技能
- 用具体案例展示项目管理、跨部门/跨国协作的成功经验，以及用英语进行学术汇报或沟通的实例
- 如有发表的高质量论文、专利申请或会议报告，务必列出，这是证明科研能力和行业影响力的关键
- 若对慢病毒载体操作或特定基因编辑平台不熟悉，可针对性学习相关实验原理、protocol和最新文献
- 加强生物医药行业法规（如GCP, GLP）及中国相关合规要求（如HGR）的了解，这在药企研发中日益重要
面试指南
- 对于技术问题，采用“背景-任务-行动-结果”结构，清晰阐述技术细节、个人角色、决策逻辑和最终成果
- 对于行为或协作问题，重点展示你的沟通方式、问题解决过程、如何平衡多方意见以及推动项目前进的具体行动
- 在回答中自然地融入对行业趋势、技术难点的思考，展现你的科学素养和批判性思维，而不仅仅是执行者
- 请详细介绍你过去在细胞疗法或基因编辑领域最有挑战性的一个研发项目，你具体负责什么，遇到了什么困难，如何解决的？
- 你如何理解同种异体CAR-T相较于自体CAR-T的技术挑战和优势？请谈谈相关的技术策略
- 请描述一次你需要与不同背景或部门的同事紧密协作以完成项目的经历
- 你如何确保沟通有效和项目推进？
- 如果你的实验数据与预期不符或项目遇到重大技术瓶颈，你会如何分析和应对？请举例说明
职位点评
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