Principal Scientist (all genders) Structural Biology
发布于 5 小时前普通员工/个人贡献者
值不值得投
综合评分 85
A highly impactful, senior R&D role at a global pharma leader offering cutting-edge tech and strong purpose, with lifestyle details unspecified.
从薪资福利、成长发展、工作生活和使命价值四个维度综合评估，方便横向比较。
薪资怎么样
7.8万
比药物研发中位数高
发布情况
新岗位 · 今天发布
公司情况
这家公司招聘很活跃
约 130 个在招
市场机会
选择面较广
药物研发 · 约 110 个在招
职位详情
关于这个职位
As a Principal Scientist in Structural Biology, you will lead interdisciplinary projects to elucidate structural mechanisms and enable structure-based drug design, focusing on macromolecular complexes. You will strengthen X-ray crystallography and cryo-EM capabilities, manage CRO collaborations, and mentor junior scientists to drive innovative drug discovery.
最低要求
PhD in Structural Biology or a related field with 10+ years of relevant experience (including biopharma, biotech) and a strong track record to design, execute, and drive complex structural biology projects.
工作职责
Provide scientific leadership in interdisciplinary projects to elucidate structural mode of action and enable structure-based design with a focus on macromolecular complexes of antibodies, multispecifics, and molecular degraders.
优先资格
Ideally hands-on with single-particle cryo-EM and biophysical techniques (e.g., HDX-MS, SAXS; Refeyn, FIDA, DSF).
AI 洞察
优缺点分析
优点
- Opportunity to work on cutting-edge structural biology techniques (X-ray, cryo-EM, AI/ML) in a top-tier global pharmaceutical company.
- High impact on drug discovery for major therapeutic areas like oncology and immunology.
- Strong mentorship and leadership development opportunities within a collaborative culture.
- High complexity of macromolecular complexes requiring advanced problem-solving and technical troubleshooting.
- Managing multiple CROs and cross-functional stakeholders can be demanding and require strong coordination skills.
- Highly experienced structural biologists with a strong publication record and a passion for translating structural insights into tangible drug discovery outcomes.
缺点 / 挑战
暂无明显挑战项
角色解读
- Progression to Director or VP of Structural Biology roles.
- Transition into broader R&D leadership positions overseeing multiple drug discovery programs.
- Lead interdisciplinary structural biology projects to determine the 3D structures of macromolecular complexes like antibodies and molecular degraders.
- Drive end-to-end experimental strategies using X-ray crystallography and cryo-EM to enable structure-based drug design.
- Mentor junior scientists and coordinate with CROs to accelerate drug discovery pipelines.
- Deep expertise in X-ray crystallography and protein complex structure determination.
- Strong background in biophysics and experience with CRO management.
- Excellent scientific communication and cross-functional leadership skills.
申请策略
- Tailor your cover letter to Merck's mission of 'Sparking Discovery and Elevating Humanity' and highlight your collaborative mindset and commitment to diversity and inclusion.
- Highlight specific achievements in solving complex protein structures (antibodies, degraders) and how they directly impacted drug design.
- Showcase experience in managing CROs and leading cross-functional teams.
- Emphasize proficiency in both X-ray crystallography and emerging techniques like cryo-EM or AI/ML.
- Gain hands-on experience with single-particle cryo-EM if not already proficient.
- Familiarize yourself with AI/ML-based biomolecular structure prediction tools and HPC cloud environments.
面试指南
- Use the STAR method (Situation, Task, Action, Result) to detail specific projects. Focus on the scientific rationale, technical challenges overcome, and the ultimate impact on the drug discovery pipeline.
- Can you walk us through a complex structural biology project you led from sample generation to structure-based drug design?
- How do you approach integrating X-ray crystallography with cryo-EM and biophysical techniques?
- Describe your experience in managing CROs and coordinating multi-site projects.
- How do you mentor junior scientists and foster a collaborative team culture?
- Review Merck's recent pipeline and therapeutic focus areas (oncology, immunology, neuroscience).
- Be prepared to discuss the latest advancements in structural biology, including AI-driven structure prediction and its practical applications in drug design.
职位点评
薪资福利
The position offers a highly competitive salary for a senior scientific role in Germany, reflecting the extensive experience required and the strategic importance of the role.
成长发展
The role provides excellent opportunities to work with cutting-edge technologies and offers strong mentorship and leadership development within a global R&D environment.
工作生活
While the JD does not explicitly detail work-life balance policies, senior roles in global pharma R&D typically offer stable working hours, though project deadlines and CRO coordination may require flexibility.
使命价值
The role is deeply aligned with the company's mission to enrich people's lives and champion human progress through innovative healthcare and life science solutions.
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