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Senior Principal Scientist I, Translational Disease Biology
Senior Principal Scientist I, Translational Disease Biology
发布于 大约 14 小时前普通员工/个人贡献者
Vitry-sur-Seine, France
高级经验
全职员工
混合式弹性办公
博士
研究与开发 (研发)
AI/ML
Cross-Functional Leadership
Multi-Omics
Single-Cell Transcriptomics
Translational Biology
AI 估算 · 45k–60k
Senior Principal Scientist 在法国药企，经验要求高，技术含量高，薪资在行业中等偏上。
职位详情
关于这个职位
This role is a Senior Principal Scientist focusing on translational disease biology. You will lead cross-functional projects to drive novel target identification, asset positioning, and precision medicine strategies. It requires deep expertise in immunology or oncology, and the ability to integrate multi-omics data with AI/ML approaches.
最低要求
Experience: Experience in pharmaceutical or biotech industry with demonstrated expertise in Immunology & Inflammation, Oncology/IO, or related therapeutic areas. Proven track record leading cross-functional teams across research, translational, and development functions. Experience coordinating external collaborations and driving prioritization across multiple organizational functions. Experience operating in international biotech/pharma/research ecosystems.
Technical and Soft Skills: Deep mechanistic expertise in disease biology (I&I or Onco/IO) with ability to develop compelling therapeutic hypotheses grounded in translational evidence. Demonstrated ability to bridge biological insight with quantitative analytical outputs and integrate across scientific disciplines. Proficiency in handling multi-modal data integration, statistical analysis, and visualization. Experience applying AI/ML tools to biological data and hands-on experience with bulk and single-cell/spatial transcriptomics and proteomics. Outstanding written and oral English communication for audiences from bench scientists to senior leadership and external KOLs. Ability to translate complex multi-omics analyses into clear, decision-grade biological narratives.
Education: PhD, PharmD, and/or MD in a relevant scientific discipline with 5 years pharmaceutical/biotech industry experience; or Master's degree with 10 years of pharmaceutical/biotech industry experience.
Languages: Proficiency in both French and English (written and spoken).
工作职责
Lead cross-functional projects across TDSB, Immunology & Inflammation (I&I) or Oncology/IO Therapeutic Areas, driving novel target identification, credentialing, asset positioning, and program advancement
Champion reverse-translational efforts that bring learnings from molecular and clinical data back into the early-stage research portfolio to sharpen hypotheses and accelerate decisions
Own and drive cross-functional initiatives with the Translational Medicines Unit for the development and application of precision medicine strategies to pipeline programs
Lead Sanofi's engagement with external stakeholders including vendors, academic consortia, and pre-competitive partnerships, ensuring alignment with strategic objectives
Lead integrated multi-modal analyses, operating fluently in both disease biology and quantitative methods, driving the analytical/computational agenda and translating outputs into biological narratives that inform portfolio decisions
Define compelling therapeutic hypotheses grounded in mechanistic disease understanding and lead scientific framing of disease heterogeneity, treatment responses, and patient stratification strategies
Direct evaluation of in vitro and in vivo model relevance to diseases and disease subsets, developing approaches to explore drug mechanisms-of-action and combination therapeutic strategies
Represent Sanofi at scientific conferences and strategic gatherings, driving life-cycle management strategies for current assets in partnership with global project teams
AI 洞察
优缺点分析
优点
- Work at the forefront of drug discovery with cutting-edge AI and multi-omics technologies.
- Lead high-impact projects that directly influence pipeline decisions and patient outcomes.
- Strong emphasis on professional development and international mobility.
- Requires balancing deep scientific expertise with cross-functional leadership.
- High expectations for translating complex data into clear narratives for diverse stakeholders.
- May involve significant travel and external engagement.
- An experienced scientist with a PhD and strong background in immunology/oncology, who thrives in a collaborative, data-rich environment and seeks to influence translational strategy.
缺点 / 挑战
暂无明显挑战项
角色解读
- Progress to leadership roles in translational medicine or therapeutic area head.
- Opportunities to shape portfolio strategy and drive precision medicine initiatives.
- Potential for cross-functional and international mobility within Sanofi.
- Lead cross-functional projects targeting novel target identification and asset positioning in immunology or oncology.
- Integrate multi-omics data and apply AI/ML to drive translational strategies and precision medicine.
- Engage external partners and represent Sanofi at scientific conferences.
- Deep mechanistic expertise in disease biology (I&I or Onco/IO) with translational evidence.
- Proficiency in multi-omics data integration, statistical analysis, and AI/ML applications.
- Strong leadership and communication skills to bridge biology and quantitative outputs.
申请策略
- Tailor your application to demonstrate how your expertise aligns with Sanofi's focus on immunology and AI-powered R&D.
- Prepare concrete examples of how you have influenced portfolio decisions through translational insights.
- Highlight your experience leading cross-functional teams and driving translational projects.
- Showcase hands-on skills in multi-omics data analysis, AI/ML, and precision medicine.
- Emphasize your ability to communicate complex biology to both technical and non-technical audiences.
- Strengthen your knowledge of single-cell/spatial transcriptomics and proteomics.
- Deepen your understanding of AI/ML methods applied to biological data.
- Polish your French language skills to meet the bilingual requirement.
面试指南
- Use the STAR method (Situation, Task, Action, Result) for behavioral questions.
- For technical questions, outline the problem, your analytical approach, and the impact on decision-making.
- Emphasize collaboration and your role as a bridge between biology and data science.
- Describe a time you led a cross-functional team to advance a target from research to translational stage.
- How would you integrate multi-omics data to identify patient stratification biomarkers?
- Tell us about an experience using AI/ML to derive biological insights from complex datasets.
- How do you communicate complex translational data to senior leadership?
- Why are you interested in Sanofi and this specific role?
职位点评
85
综合评分
Senior Principal Scientist in translational biology with high development potential, strong WLB, and meaningful social impact; compensation is competitive but undisclosed.
更适合这类人
This role is best suited for a scientist who values cutting-edge technology, professional growth, and meaningful work in drug discovery. Compensation is competitive but not the primary draw.
表现最好
成长发展
相对薄弱
薪资福利
薪资福利75
成长发展92
工作生活85
使命价值88
薪资福利
75中等
Fixed salary over 12 months with short-term incentive, comprehensive benefits (health insurance, parental leave, pension), and transportation subsidy. While exact salary not disclosed, typical for senior roles in big pharma in France is competitive.
薪资信号未披露（AI估算：45K-60K/月）
福利待遇health insurance、extended maternity/parental leave (18/14 weeks)、teleconsultation、second medical opinion、31 days paid leave + RTT、remote work up to 2 days/week、public transport coverage up to 80%、Group Savings Plan and PERCOL with employer matching、PERO、peer-to-peer recognition & service exchanges、CSE benefits
成长发展
92较高
The role involves cutting-edge AI/ML and multi-omics technologies, with strong emphasis on professional development, internal mobility, and career paths for scientific leadership. JD explicitly mentions learning opportunities and structured career paths.
技术前沿前沿/新兴技术
技术栈AI/ML、multi-omics、single-cell transcriptomics、proteomics、spatial transcriptomics
成长机会Internal and international mobility opportunities、learning & development opportunities、structured career paths designed for both scientific and leadership advancement
业务类型profit_center
工作生活
85较高
Hybrid work (up to 2 days remote per week), 31 days paid leave plus RTT, good work-life balance signals. Office location in Vitry-sur-Seine near Paris, with excellent public transport coverage.
工作模式混合式弹性办公 (2)
办公地点科技园/产业园
加班情况未提及（无法判断）
工作生活平衡31 days of paid leave + RTT、remote work up to 2 days/week、public transport coverage up to 80%
使命价值
88较高
Sanofi's mission to improve lives through immunology and AI-powered research, with direct impact on patients. The role contributes to developing new medicines and precision medicine strategies, which has high social value.
行业发展高速增长赛道
社会影响正向社会影响力较高
使命信号chase the miracles of science to improve people's lives、improve the lives of millions of people globally
创新程度积极采用新技术
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