默克药厂
Senior Manager, R&D
Senior Manager, R&D
发布于 3 小时前中层管理(经理/总监)
AI 估算 · 7.85–12.12万 · AI 参考估算
Milwaukee, Wisconsin, United States
专家级经验
博士
全职员工仅现场办公药物研发
药物研发
Adcs
Protacs
值不值得投
76综合评分
综合评分 76
Frontier chemical biology R&D leadership with strong pay and scientific growth, but hands-on, high-responsibility, and unclear WLB.
从薪资福利、成长发展、工作生活和使命价值四个维度综合评估，方便横向比较。
薪资怎么样
10万
比药物研发中位数高
发布情况
新岗位 · 今天发布
公司情况
这家公司招聘很活跃
89 个在招
市场机会
选择面较广
药物研发 · 约 110 个在招
职位详情
关于这个职位
A senior R&D leadership role at MilliporeSigma (Merck KGaA) within Chemical Synthesis Solutions, acting as the scientific bridge between chemistry and biology. You will design and run biochemical and cell-based assays, lead protein/peptide, medicinal chemistry, and DNA-Encoded Library (DEL) work, and drive mechanism-of-action and proof-of-concept validation for novel modalities such as ADCs, ASOs, and targeted protein degraders. The role also leads a cross-disciplinary sub-team, owns the sub-team budget, and shapes a 5–10 year chemical biology capability roadmap.
最低要求
PhD in Chemical Biology, Medicinal Chemistry, Bioorganic Chemistry, Biochemistry, or a closely related discipline with a strong chemical biology component.
Minimum 10 years of post-doctoral R&D experience in pharma, biotech, or life science tools (industry or academic), with a demonstrated track record spanning both chemistry and in vitro biology.
Deep, hands-on expertise in chemical biology: chemical probe design and synthesis, ABPP, photoaffinity labeling, chemoproteomics, or equivalent target identification and MOA methodologies.
Strong protein and peptide chemistry expertise: SPPS/LPPS, peptide conjugation, cyclic/stapled peptide design, site-specific protein modification, and bioconjugation strategies for ADCs, PROTACs, and peptide therapeutics.
Solid medicinal chemistry literacy: SAR, ADME, selectivity optimization, and drug-likeness principles applied to small molecules, peptides, and chemical probes.
Deep technical expertise in mammalian cell culture, biochemical and cell-based functional assays, binding assays, and protein labeling — with the ability to independently design, develop, and execute these workflows — and a strong focus on characterizing novel modalities (ASOs, RNA, proteins, ADCs, peptide drugs, PROTACs, etc.).
Comprehensive understanding of MOA study design across diverse therapeutic target classes (kinases, proteases, E3 ligases, nucleic acid targets, GPCRs, etc.).
Hands-on expertise in the construction and utilization of DNA-Encoded Libraries (DELs-ssDELs, dsDELs), encompassing library design, split-and-pool synthesis, DNA-compatible chemistry, affinity selection screening, and hit deconvolution/sequencing analysis.
Proven track record leading R&D teams: sustaining scientific performance, managing cross-domain project portfolios, and driving deliverables from concept to validated output.
Strong strategic and analytical skills: able to connect scientific workflows to business outcomes, project milestones, and budget accountability.
Excellent communication skills: experienced in presenting complex chemical biology and in vitro data to multidisciplinary audiences including senior leadership, customers, and KOLs.
This role does not offer sponsorship for work authorization; external applicants must be eligible to work in the US.
工作职责
Chemical Biology & Medicinal Chemistry Interface
Design and synthesize chemical probes, tool compounds, and novel building blocks; apply SAR, ADME, and selectivity principles to guide prioritization of CSS chemical candidates and platform molecules.
Lead protein and peptide chemistry within CSS R&D: solid-phase/liquid-phase peptide synthesis (SPPS/LPPS), cyclic and stapled peptide design, site-specific protein modification, and antibody conjugation strategies for ADCs, PROTACs, ASOs and peptide therapeutics.
Lead the design and synthesis of novel DELs (encompassing membrane-DEL and proximity-DEL) and integrate DEL-derived insights to streamline and accelerate validation of screening hits.
Provide expert guidance on linker chemistry, bioconjugation, and payload design for novel modalities (ADCs, TPDs, peptide–drug conjugates, ASO-based therapeutics, as well as RNAs).
Deploy chemical biology approaches — activity-based protein profiling (ABPP), photoaffinity labeling, chemoproteomics, chemical genetics — to interrogate target biology and support target identification workflows.
In Vitro Biochemical & Cell-Based Assay Development
Independently design, develop, optimize, and execute a comprehensive suite of in vitro biochemical and cell-based assays: binding assays (TR-FRET, AlphaScreen, SPR, fluorescence polarization), enzyme activity assays, cellular target engagement assays (CETSA, NanoBRET), and functional/phenotypic assays.
Apply protein labeling techniques — fluorescent labeling, biotinylation, crosslinking, affinity enrichment, pull-down, and co-immunoprecipitation — to support target deconvolution and MOA studies.
Maintain mammalian cell culture capabilities required for functional assay execution and PoC validation of CSS chemical candidates and platforms.
Provide deep technical expertise in the in vitro characterization of novel therapeutic modalities: peptide drugs, ADCs, ASOs, siRNA/mRNA constructs, proteins, and targeted protein degraders, including assessment of cellular uptake, target engagement, and functional activity.
Establish and enforce assay quality standards (Z'-factor, S/N ratio, CV, reproducibility) to ensure data integrity and scientific rigor across all biological testing activities.
MOA Studies, Target Identification & Proof-of-Concept Validation
Serve as the primary scientific resource for MOA studies and PoC validation across CSS chemical candidates and proprietary platforms; define experimental strategies, execute studies, and deliver clear, decision-enabling data packages with explicit go/no-go criteria.
Lead target identification and target engagement experiments using chemical biology (ABPP, photoaffinity labeling, chemoproteomics) and biochemical approaches (binding assays, CETSA, NanoBRET).
Validate proprietary CSS building blocks, linker platforms, late-stage functionalization (LSF) reagents, and screening libraries through relevant biological assays; translate findings into scientific narratives that support product positioning and IP strategy.
Novel Modalities & Capability Strategy
Define and execute a 5–10 year chemical biology and in vitro biology capability roadmap for CSS, aligned to the Innovation Strategy 2030 and LS Innovation Vectors (Novel Modalities, Next-Generation Biology).
Expand CSS capabilities in novel therapeutic modalities — peptide drugs, ADCs, ASOs, RNA therapies, targeted protein degraders — identifying and closing capability gaps that limit customer workflow support.
Monitor the competitive landscape, scientific literature, and patent environment; identify breakthrough innovation opportunities and translate them into actionable R&D investment proposals.
Integrate automation, miniaturization, and AI/ML tools into chemical biology and assay workflows to accelerate the Design-Make-Test-Learn (DMTL) cycle.
Cross-Domain Portfolio Leadership & Operations
Lead and develop a cross-disciplinary sub-team spanning chemical biology, biochemistry, and protein/peptide chemistry; provide scientific direction, mentorship, and performance management.
Sustain strategic momentum across adjacent domains including next-generation biomaterials, 3D bioprinting, and drug delivery; apply TRL/CRL frameworks to assess project maturity and protect delivery timelines against stage-gate criteria.
Own the sub-team budget (CAPEX and OPEX): plan, forecast, track, and control spend; develop compelling business cases (NPV, TAM/SAM/SOM) for new capability investments.
External Partnerships, KOLs & Innovation
Build and maintain a collaborative network across CSS R&D, Medicinal Chemistry, Materials Science, Engineering & Digital, and Business Development, as well as external partners (CROs, CDMOs, academic institutions).
Engage customers, Key Opinion Leaders, and scientific advisory boards to translate market needs into actionable R&D roadmaps; represent CSS at scientific conferences and customer-facing engagements.
Identify patentable inventions arising from chemical biology and protein/peptide work; manage IP disclosures and collaborate with legal teams on freedom-to-operate assessments.
Champion sustainability and green chemistry practices within chemical biology workflows; foster a culture of continuous learning and scientific excellence across the team.
优先资格
Experience with targeted protein degradation (PROTAC/molecular glue) chemistry and associated cellular validation assays (FACS-based degradation, western blot, TR-FRET, NanoBRET).
Familiarity with nucleic acid-based modalities (ASO, siRNA, mRNA) and their chemical modification strategies (phosphorothioate, 2'-OMe, LNA) and functional cellular readout assays.
Experience integrating automation, liquid handling, and AI/ML tools into chemical biology or assay workflows to accelerate the DMTL cycle.
Track record managing diverse portfolios beyond traditional drug discovery (biomaterials, 3D bioprinting, drug delivery, multi-omics platforms).
Experience with biophysical target engagement techniques (SPR, ITC, CETSA, X-ray crystallography, cryo-EM) applied to MOA studies.
Familiarity with IP identification, protection, and patent strategy in a Life Science R&D or tools/reagents context.
Track record of successful external collaborations (academic institutions, CROs, industry partners) resulting in co-developed products, publications, or IP.
AI 洞察
优缺点分析
优点
- Works at the frontier of chemical biology and novel therapeutic modalities (DEL, ADCs, ASOs, PROTACs).
- Combines hands-on science with leadership, budget ownership, and strategic roadmap influence.
- Backed by a large global life-science organization with broad customer and collaboration networks.
- Carries a clear scientific mission of advancing drug discovery and improving lives.
- Very broad dual-domain scope spanning chemistry, biology, assay development, and team leadership.
- Requires a rare combination of 10+ years of experience across both chemistry and in vitro biology.
- High accountability for portfolio decisions, budget, and IP, with substantial stakeholder expectations.
- Suited to a PhD-level scientist with deep chemical biology and assay expertise who is ready to lead a cross-disciplinary team and shape strategy in a large life-science company.
缺点 / 挑战
暂无明显挑战项
角色解读
- Expand into broader R&D portfolio and capability leadership as the CSS chemical biology roadmap grows.
- Build cross-functional influence across Medicinal Chemistry, Materials Science, Engineering & Digital, and Business Development.
- Establish external scientific standing through KOL engagement, publications, and IP contributions.
- Serve as the scientific bridge between chemistry and biology, designing and executing in vitro biochemical and cell-based assays to validate chemical hypotheses.
- Lead protein/peptide chemistry and DNA-Encoded Library (DEL) design, and guide linker and bioconjugation chemistry for novel modalities (ADCs, ASOs, PROTACs).
- Drive MOA studies and proof-of-concept validation of CSS chemical products and platforms, delivering decision-enabling go/no-go data packages.
- Lead a cross-disciplinary sub-team, own the sub-team budget, and shape a 5–10 year chemical biology capability roadmap.
- Deep hands-on chemical biology expertise: probe design and synthesis, ABPP, photoaffinity labeling, and chemoproteomics.
- Strong protein and peptide chemistry skills: SPPS/LPPS, cyclic/stapled peptides, bioconjugation, and site-specific protein modification.
- Ability to independently design, develop, and run biochemical and cell-based assays and mammalian cell culture.
- Proven R&D team leadership, cross-domain portfolio management, and budget ownership.
申请策略
- Emphasize the chemistry–biology bridge, since the JD describes it as the role's defining quality.
- Note that the role offers no work-authorization sponsorship, so confirm and state your US work eligibility early.
- Highlight dual-domain expertise that bridges chemistry and biology — the core of this role.
- Quantify DEL design, split-and-pool synthesis, and affinity screening achievements and their outcomes.
- Showcase team leadership: team size, budget ownership, and cross-functional and external partnerships.
- Demonstrate novel-modality experience (ADCs, ASOs, PROTACs) with concrete assay-development results.
- Strengthen familiarity with AI/ML and automation applied to assay and DMTL workflows.
- Deepen knowledge of nucleic acid modality chemistry (ASO, siRNA, mRNA modifications).
面试指南
- Use STAR to describe scientific programs: the hypothesis, the assays/probes you designed, the data, and the decision it enabled.
- For leadership questions, show how you set scientific direction, mentored staff, and managed budgets and timelines.
- For strategy questions, link scientific work to customer needs, portfolio value, and IP.
- Can you walk us through a specific chemical biology program where you designed probes and in vitro assays to validate a target or mechanism of action?
- How have you designed, synthesized, and applied DNA-Encoded Libraries to accelerate screening and hit validation?
- How do you lead a cross-disciplinary team spanning chemistry, biochemistry, and protein/peptide chemistry?
- How do you prioritize a portfolio of novel-modality projects (ADCs, ASOs, PROTACs) against stage-gate and budget criteria?
- How do you connect R&D work to business outcomes such as product positioning and IP strategy?
职位点评
薪资福利82
成长发展86
工作生活50
使命价值78
薪资福利
82较高
The JD discloses a base salary range and standard benefits (health insurance, PTO, retirement contributions), plus possible sales or performance-based bonuses — a solid package for a senior R&D leadership role.
薪资信号市场水准 (7.85千–12.12万/月)
福利待遇health insurance、paid time off (PTO)、retirement contributions、sales or performance-based bonuses
成长发展
86较高
Highly developmental: the role sits at the frontier of chemical biology, DEL, and novel therapeutic modalities, with leadership over a cross-disciplinary team and a mandate to shape a long-term capability roadmap.
技术前沿前沿/新兴技术
技术栈Chemical Biology、DNA-Encoded Libraries (DEL)、Medicinal Chemistry、SPPS/LPPS、ABPP、Chemoproteomics、ADCs、PROTACs、ASOs、TR-FRET、SPR、CETSA、NanoBRET
成长机会mentorship、develop and grow at your own pace、foster a culture of continuous learning
业务类型ambiguous
工作生活
50较低
The JD describes hands-on lab, cell-culture, and assay responsibilities but does not state the work mode or working-hours expectations, so flexibility and WLB cannot be confirmed.
工作模式未明确
办公地点未明确
加班情况未提及（无法判断）
使命价值
78中等
The role advances drug discovery for novel therapeutic modalities and life-science tools within an organization whose stated mission is to enrich people's lives, giving it clear positive social impact.
行业发展稳定成熟行业
社会影响正向社会影响力较高
使命信号enrich people's lives、Sparking Discovery and Elevating Humanity、Healthcare, Life Science, and Electronics、caring for our rich mix of people, customers, patients, and planet
创新程度积极采用新技术
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