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葛兰素史克
Director, Translational Lead, Renal, Hepatology, Cardiovascular Diseases
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Director, Translational Lead, Renal, Hepatology, Cardiovascular Diseases

发布于 大约 2 小时前

中层管理(经理/总监)

上海市
高级经验
全职员工
仅现场办公
博士
临床研究
Cro Management
Matrix Leadership
Metabolic Dysfunction
Regulatory Affairs
Rna/Genomics

AI 估算 · 50k–80k

资深转化医学总监岗位，上海外企，博士+5年经验，薪资水平在行业前列，但未明确数字，参考市场范围。

职位详情

关于这个职位

该职位是GSK上海研发中心的转化科学负责人，专注于代谢性疾病（肾、肝、心血管）领域的转化研究与生物标志物开发

你将领导中国区的转化策略，与全球团队合作设计并执行临床生物标志物研究，推动药物从早期研发到临床阶段的转化
适合资深转化医学科学家，需具备博士学历和5年以上行业经验

最低要求

Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field) with minimum of 5 years relevant industry experience in the application of biomarkers in clinical trials.

Experience in translational science and biomarker development in a clinical trial setting within the pharmaceutical or biotechnology industry.
Metabolic dysfunction disease area knowledge and understanding in translational/biomarker development and implementation.
Experience of working in a clinical trial setting, working as part of a clinical study team and experience of authoring and oversight of clinical and regulatory documents.
Demonstrated experience analyzing and interpreting clinical biomarker data to inform development decisions.
Strong working knowledge of biomarker technologies, assay platforms, and GCP principles.
Knowledge of regulatory requirements, industry standards, best practices and compliance considerations in Translational Research and biomarker development and validation.
Experience in managing external collaborations with academic partners and CROs.
Strong interpersonal, matrix leadership and communication skills as well as ability to thrive in a matrix environment.
Proficient in both English and Chinese.

工作职责

Lead Metabolic Dysfunction Translational Strategy in China

Lead and/or contribute to developing innovative translational strategies in metabolic dysfunction for assets ranging from preclinical to clinical stage of development.
Develop biomarker strategies aligned with clinical development plans to generate data that informs on target engagement, pharmacodynamics, mechanism of action and patient stratification/selection.
Drive Biomarker Execution & Data Delivery
Oversee implementation of biomarker assays and testing strategies, ensuring timely, high-quality data generation and reporting to support clinical development, integrated evidence plan and regulatory decision-making.
Provide scientific expertise and technical guidance to enable timely biomarker sample collection and analysis including from high dimensional assays to deliver high quality biomarker data.
Provide input on biomarker-related elements of clinical study documentation for study start and reporting of biomarker data generated from clinical trials.
Operate Effectively in a Matrixed Development Environment
Represent Asia R&D and Translational Sciences functions in China at Early Development Team (EDT), Clinical Matrix Teams (CMT) and clinical trial study teams (ST). As part of the CMT and clinical ST, establish clear decision-making criteria to enable biomarker-informed clinical decisions.
Collaborate with cross-functional teams including clinical, translational sciences, biology, and medical affairs to ensure end-to-end biomarker data generation for asset needs and reverse translation to support the pipeline.
Enable Regulatory, External, and Innovation Impact
Provide biomarker and diagnostic support for regulatory submissions and region-specific governance processes.
Identify biomarker/diagnostics data gaps in metabolic dysfunction and broader translational sciences and conduct landscaping of Asia external innovation and establish strategic scientific external partnerships.
Manage interactions with external laboratories, vendors, and collaborators, and maintain awareness of emerging biomarker technologies and innovation trends across Asia.
Foster a network of external experts and key opinion leaders to stay at the forefront of translational science and biomarker advancements across the industry.
Provide translational input and oversight on biomarker related activities for scientific collaborations.

优先资格

Demonstrated scientific capability as evidenced by publications, research reports, and external presentations.

Up to date knowledge and deep understanding of major molecular and genomic assay technologies and platforms.
Hands-on experience in bioinformatic analysis.
Experience with novel technologies e.g., spatial transcriptomics and AI/ML.
Knowledge and expertise in Fibrosis and ECM Biology.
Knowledge and experience in metabolic dysfunction diseases.

AI 洞察

优缺点分析

优点

  • 全球顶尖药企研发岗位，接触前沿技术和管线，影响力大
  • 上海作为亚洲研发中心，有较多自主权和资源，参与全球战略
  • 代谢疾病领域需求大，职业发展前景广阔
  • 工作强度高，需同时管理多个项目并协调全球团队
  • 岗位要求极高，需博士学历和多年经验，竞争激烈
  • 矩阵式管理复杂，需要强大的政治智慧和沟通能力
  • 适合有博士学历、多年制药行业转化医学经验，擅长跨部门协作，希望在代谢疾病领域深入发展的资深科学家

缺点 / 挑战

暂无明显挑战项

角色解读

  • 向上可晋升为全球转化科学负责人或研发副总裁，领导更大范围的疾病领域策略
  • 横向可转向临床开发或医学事务部门，或专注早期研发管理
  • 在GSK内部或外部均可成为转化医学领域的顶尖专家，影响力覆盖行业标准制定
  • 负责制定代谢性疾病（肾、肝、心血管）领域的转化研究策略，涵盖从临床前到临床阶段的生物标志物开发
  • 领导并执行生物标志物检测方案，确保临床数据的高质量生成，支持靶点验证、药效学和患者分层
  • 在矩阵式研发环境中与全球团队协作，参与早期开发团队、临床矩阵团队，推动生物标志物驱动的临床决策
  • 为监管申报提供生物标志物和诊断支持，管理外部合作伙伴关系，跟踪前沿技术
  • 深厚的转化医学和生物标志物开发经验，尤其在代谢性疾病领域
  • 精通临床试验设计和监管要求（GCP），具备分析临床生物标志物数据的能力
  • 强大的矩阵领导力和跨部门协作能力，能有效沟通中英文
  • 熟悉高通量检测技术（如基因组学、蛋白质组学）和生物信息学分析

申请策略

  • 在求职信中明确表达对GSK使命的认同及对代谢疾病领域的热情
  • 主动联系内部推荐人或参加GSK的行业会议增加曝光
  • 突出在代谢疾病转化研究中的具体成果，如成功推动候选药物进入临床或关键的生物标志物发现
  • 强调领导跨功能团队的经验，包括与临床、监管、外部合作方的互动
  • 列举发表的论文、专利或行业报告，证明科学影响力
  • 中英文简历均需准备，重点展示双语沟通能力
  • 若缺乏生物信息学经验，可短期学习R/Python基础分析
  • 关注新兴技术如空间转录组学、AI/ML在生物标志物中的应用

面试指南

  • STAR法则：描述情境、任务、行动和结果，强调数据驱动决策
  • 展示系统思维：从科学问题到策略落地，兼顾全球合规和区域特点
  • 突出协作：举例说明如何说服不同背景的同事接受你的方案
  • 请描述一个你主导的转化研究项目，如何从生物标志物发现到临床验证？
  • 如何在矩阵环境中推动不同团队达成共识？
  • 你如何评估一个新的生物标志物技术的价值并决定是否采用？
  • 谈谈你在代谢疾病领域的经验，尤其是肾、肝或心血管方向
  • 如何确保临床试验中生物标志物数据符合监管要求？

职位点评

72
综合评分

GSK上海转化医学总监，前沿技术导向，高成长高意义，但工作强度大，WLB受限。

从薪资福利、成长空间、工作节奏和岗位方向综合评估，方便横向比较。

更适合这类人
适合优先考虑职业成长与意义感，对薪资满意且能接受较高工作强度的资深科学家。
表现最好
成长发展
相对薄弱
工作生活
薪资福利75
成长发展85
工作生活40
使命价值85

薪资福利

75中等

薪资水平在行业偏高，但未明确公开，福利未在JD中提及，总体满足度中等偏上。

薪资信号未披露（AI估算：50K-80K/月）

成长发展

85较高

岗位提供全球顶尖平台、前沿技术（空间转录组学、AI/ML）和清晰的职业发展路径，成长性较好。

技术前沿前沿/新兴技术
技术栈生物标志物、空间转录组学、AI/ML、基因组学
业务类型profit_center

工作生活

40较低

上海办公室现场办公，未提及灵活工作安排，工作强度可能较高，WLB一般。

工作模式仅现场办公
办公地点市区核心地段
加班情况未提及（无法判断）

使命价值

85较高

GSK致力于改善全球健康，代谢疾病领域有巨大社会价值，创新性强，意义感较高。

行业发展高速增长赛道
社会影响正向社会影响力较高
使命信号get ahead of disease together、improve the lives of billions
创新程度积极采用新技术

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